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ea0081p606 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The ecology of the microbiome in children with congenital generalized lipodystrophy type 4 (CGL4) is quickly modified after metreleptin treatment

Daffara Tommaso , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Massa Nadia , Caramaschi Alice , Mignone Flavio , Romanisio Martina , Rabbone Ivana , Giordano Mara , Aimaretti Gianluca , Bona Elisa , Prodam Flavia

Introduction: Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and genetic background. The role of microbiota is still uninvestigated.Objective: Evaluate the gut microbiome ecology in relation to dietary and clinical parameters in two infant siblings with congenital generalized lipodystrophy type 4 (CGL4) before and after treatment with recombinant leptin.Method...

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Endocrine Abstracts

The ecology of the microbiome in children with congenital generalized lipodystrophy type 4 (CGL4) is quickly modified after metreleptin treatment

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